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Researchers at the Indian Institute of Technology (IIT) Kanpur have revealed new insights into how cholesterol-lowering drugs like niacin work at the molecular level.
According to a press release issued by the institute, Professor Arun K. The team of researchers from the Department of Biological Sciences and Bioengineering led by Shukla were able to visualize the key target receptor molecule activated by niacin and other related drugs. This research has the potential to develop new cholesterol-lowering drugs with fewer side effects.
The release said that the research findings have been published in the international journal, Nature Communications.
Speaking on the research, Professor Shukla said that niacin is a commonly prescribed medicine to reduce bad cholesterol and triglycerides and increase good cholesterol. “In many patients, the drug causes side effects such as skin redness and itching, called flushing reactions. This leads patients to discontinue their treatment and adversely affects their cholesterol levels,” he said.
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Professor Shukla highlighted that the visualization of receptor molecules with niacin at the molecular level lays the groundwork for the creation of new drugs that maintain efficacy while minimizing undesirable reactions, adding that the results would be useful for related drugs for cholesterol. And will help develop drugs for other conditions. As in multiple sclerosis.
Director of IIT Kanpur, Prof. S. Ganesh called the research a significant breakthrough as it deepens the understanding of drug-receptor interactions and opens new avenues for the design of better therapeutic agents.
Notably, the study has been supported by the Science and Engineering Research Board (SERB). The research team includes Dr Manish Yadav, Parishmita Sarma, Jagannath Maharana, Manisankar Ganguly, Sudha Mishra, Annu Dalal, Nashrah Zaidi, Sayantan Saha, Gargi Mahajan, Vinay Singh, Saloni Sharma, and Dr Ramanuj Banerjee, spearheaded by Prof Shukla.
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