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London [UK],
The conclusions published in the journal pen provide new insight on how infants develop the ability to process pain in the brain and are important implications for newborn care, especially for preterum babies.
Research, led by Professor Lorenzo Fabrie, UCL’s Neuroscience, Physiology and Pharmacology Department, discovered how various components of pain perception in early life emerge.
“Pain is a complex experience with physical, emotional and cognitive elements,” Fabrny said, “in adults,” the brain area involved in pain, collectively known as ‘pain connectom’, works together to create a full experience. In newborns, this network still matures, which may mean their pain experience is different from us. ,
The team analyzed brain scans from 372 infants, many prematurely born, using data of two of the two largest infant brain imaging projects: developing human connectum project and human connectum project.
All infants were scanned within the first two weeks of their life to ensure that the results reflect the development of the natural brain rather than the effects of postpartum experiences.
Researchers focus on three specific brain networks related to pain processing: sensory-discriminatory: responsible for identifying and detection of pain. Affection-inspired: Controls emotional response to pain. Cognitive-evaluation: Hands the interpretation and decision of pain.
The findings showed that the sensory-divine network first matures, usually between 34 to 36 weeks after conception.
This means that premature infant can also detect pain stimuli, although they can struggle to indicate where the pain is coming from.
Next, affection-Pariser Network, which gives pain to the pain, reaches functional maturity around 36 to 38 weeks.
However, cognitive-evaluation network is important to understand the importance of pain, not completely mature until 42 weeks, meaning that the newborns of the full-term still lack the development of the brain needed to understand full pain.
These findings are particularly relevant in medical settings. A pre -study of the same team in 2023 found that premature infants do not repeatedly show signs of habit for medical procedures; They continue to react as the pain is new every time. This latest study suggests that some brain network immaturity can explain that event.
“Our results suggest that preterm can weaken to be weak during the vital stages of brain development,” Professor Fabriezie said, “Saying this,” the need for pain management strategies has been highlighted that corresponds to a child’s phase of nerve development. ”
The study was funded by the UK’s Medical Research Council and included cooperation with researchers from UCLH and Kings College London.
These findings can help re -shape the clinical protocol for newborn care, especially for the weakest infants, by encouraging the time of more accurate pain management and interventions. (AI)
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