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Brain is related to cognitive decline from aging, which in turn reduces essential cognitive functions such as memory, significant thinking and more. The aging of the brain is also associated with neurodogenorable conditions such as dementia and Alzheimer’s. The scientific community is constantly trying to identify risk factors.
A study published in The Journal Psychological Medicine has identified the contribution of a major depressive disorder to increase the age of the brain, showing how people with depression may have brains that appear to be older than their real age.
Depression affects brain structure

The major depressive disorder, which is a clinical mental illness and is not the same as a temporary low mood, changes the structure of the brain. It accelerates the aging of the brain, making it look much older than the actual age of a person. Researchers behind the study targeted to examine the brain scan of 670 persons to examine the relationship, with 239 depression and without the rest. He estimated the age of the brain by assessing the thickness of various brain regions.
And in fact, in people with depression, their brain appeared much older than those who did not detect mental disorders. Changes were found in the structure of the brain, especially in the left ventral region and parts of the premiere eye field, which reflects significant thinness.
Since brain is fundamental for cognitive functions such as attention, memory, logic, and self-control, the findings of the study show new insights how these abilities can weaken in people with depression.
Why does this happen?
The study also explained the reasons behind being thinner in some brain areas. Researchers found a connection between thin and neurotransmitters levels such as dopamine, serotonin and glutamate. These are important for managing mood and cognitive abilities. When a person becomes depressed, the levels of these neurotransmitters become unbalanced, causing changes in the structure of the brain. In addition, some genes can also be active in affected areas, affecting protein binding. It is also important to note that there is also a genetic aspect of depression, which means that some genes increase the possibility of depression.
This is why it gives as much importance to mental health status as physical health. Often, many people are in the habit of reducing it, making it trivial compared to physical diseases, but the findings of this study can be understood that depression also has a physical effect, showing that it is more than just a mood disorder.
Note the readers: This article is only for informative purposes and is not an option for professional medical advice. Always consult your doctor with any question about a medical condition.
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