Non -way to deal with fungal pathogen developed, ICMR researchers did amazing, read research

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A team of researchers from the Indian Council of Medical Research (ICMR) has developed a unique way to fight a fungal pathogen called ‘Candida Albicans’ (CAL). Candida albicance is the primary cause of systemic candidiasis. Systemic candidiasis is considered a serious threat worldwide, which can lead to death in severe cases.

Researchers, including researchers, have been a multi -related approach (a method in which knowledge and skills of various subjects are used simultaneously to understand and solve any problem or skills to understand and solve the subject (IIT) researchers from the Indian Institute of Technology (IIT) Madras, which includes researchers from the Indian Institute of Technology (IIT) Madras. Can be controlled.

Research could be possible like this

The team combined computational modeling and experimental validation (experimental verification) on a large scale to identify unknown metabolism weaknesses in CAL. Dr. Susan Thomas, the chief explorer of this research and scientist at Mumbai-based ICMR-NIRCH, said, “Unlike other studies, unique integrated host-fungal metabolic models like CAL model IRV781 were merged with Human Metabolic Model Rekon 3D.”

How to help CAL Metabolism

Thomas said that this helped researchers to know how CAL metabolism reaches during host infections and was not clear or hidden metabolism weaknesses in lab culture. Along with this, it helped to highlight the role of arginine metabolism in CAL pathogen.

Prof. IBSE Faculty of WSAI, IIT Madras. Karthik Raman said, “This unprecedented new research is extremely important to diversify and improve antifungal drugs to bypass the immunity. In addition, it is aimed at improving the patient’s life rate, reduction in mortality and reducing treatment costs.”

This conclusion also underlines India’s growing strength and ability to provide solutions in interdisciplinary research, published in prestigious magazine Cell Communication and Signling.

Candida albicans are a species of fungi (yeast) that usually lives as part of the normal microbyota in the human body. It is commonly found on the mouth, throat, intestine, vagina and skin without harming healthy individuals.

It causes ‘systemic candidiasis’, a severe, aggressive fungal infection caused by the Candida species (often Candida albicans) that spreads through the mouth, skin or genital area to bloodstream and spread to internal organs.

The annual event of aggressive candidiasis in India is about 4 lakh 70 thousand. Globally, about 15,65,000 people every year have Candida bloodstream infection or aggressive candidiasis, leading to 9,95,000 deaths (63 · 6 percent).

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