Is Berberine ‘Nature’s Ozempic’ for weight loss? Bariatric surgeon explains whether supplements are worth the hype

Ozempic (semaglutide) is a prescription drug that helps people lose weight by mimicking the effects of hormones, leading to about 15% weight loss, according to Harvard Health. Berberine, on the other hand, is an over-the-counter supplement that provides modest support for metabolism similar to metformin, but with lesser effects, resulting in weight loss of about 4 pounds, according to the Oncotarget journal impact factor. Berberine works differently by activating energy sensors, so experts say it is a weaker alternative to Ozempic and not “nature’s Ozempic.” While berberine may support metabolic health, it does not match Ozempic’s ability to suppress appetite or its effectiveness. Therefore, using any treatment requires lifestyle changes to achieve sustained weight management.

What is Berberine?

Berberine is a substance found in many plants, especially those in the barberry family (genus Berberis). For many years, it has been used in traditional Chinese medicine and Ayurveda to treat a variety of health problems, including digestive problems and infections. Bariatric surgeon Dr. Ankit Potdar is telling Health Shots, “Although many people believe that berberine has health benefits, it is important to know that the FDA has not approved it to treat any medical conditions.”

What are the 5 main benefits of berberine?

Berberine, a natural compound used in traditional medicine for thousands of years, may provide many health benefits, particularly for metabolic and heart health. “Its main effect is to activate an enzyme called AMP-activated protein kinase (AMPK), which helps the body manage energy use,” the doctor says.

Here are some of the key benefits:

1. Blood Sugar Control: Berberine is known to lower blood sugar levels. “It helps improve how well cells respond to insulin and take up glucose,” the doctor shares. This may help not only people with diabetes but also those trying to control their weight.
2. Relief from PCOS: For people with polycystic ovary syndrome (PCOS), berberine may help. A study in Curious showed that women suffering from PCOS improved their body shape and hormone levels by taking this supplement.
3. Reduction in blood pressure: “Berberine may reduce high blood pressure slightly, which may help people with obesity-related high blood pressure,” says Dr. Potdar. However, it should not replace regular blood pressure medications.
4. Anti-inflammatory properties: Chronic inflammation often accompanies obesity. Berberine may reduce inflammation, which may help improve metabolic health and the body’s ability to process fats and sugars.
5. Gut Health Benefits: Our gut microbiome plays a vital role in our health and metabolism. “Berberine can aid the growth of beneficial bacteria and reduce the growth of harmful bacteria, leading to a healthy digestive system,” the expert says.

Does Berberine Really Help Weight Loss?

While berberine is not explicitly approved for weight loss, new studies suggest that it may help people lose weight. A study in Biomedicine and Pharmacotherapy found that berberine may help prevent or treat obesity and other metabolic conditions. So, how does it help in weight loss?

• Activation of AMPK: Berberine increases energy utilization and reduces fat storage by activating AMPK (AMP-activated protein kinase). This process mimics metabolic changes that occur during exercise or when you consume fewer calories.
• Effects on adipocytes: It may prevent the formation of new adipocytes while promoting the breakdown of stored fat. This action has a more direct effect on reducing body fat.

What is Ozempic (semaglutide) used for?

Ozempic is a brand name for semaglutide. This medicine helps lower blood sugar levels by increasing insulin secretion when needed. It also slows the rate at which food leaves the stomach, helping people feel full for longer periods of time. This can be an essential component of weight loss. The doctor says, “Ozempic often leads to faster, more noticeable weight loss than berberine. It is known primarily for its strong appetite-reducing effects, which are linked to its action on brain receptors that regulate appetite and cravings.”

Is Berberine Natural Ozempic?

Berberine may aid weight loss, but it works differently than Ozempic. Ozempic suppresses appetite and promotes rapid weight loss, while berberine gently supports metabolism and energy balance. It is important to have realistic expectations when considering berberine for weight loss. Although it may have some benefits, it does not work as well as Ozempic. Calling berberine “nature’s Ozempic” may be misleading because it does not provide as strong appetite control or rapid weight loss.

“If you are thinking about using berberine to aid in weight management, a typical dosage is 500 mg taken two to three times a day. It is best to take it 30 minutes to an hour before meals,” says the bariatric surgeon Neither the supplement nor Ozempic should be taken without a doctor’s advice. Ozempic usually helps to control blood sugar levels after meals and make you feel full. Keep in mind that there is no standard dosage for weight loss; Individuals may respond differently.

How long does it take to see results with berberine?

Weight loss with berberine takes time and is usually noticeable over several weeks. “If you use it consistently you may notice some changes within 4 to 12 weeks, but they will be minor,” says Dr. Potdar. For best results, most people should combine berberine with a healthy diet and regular exercise.

Does berberine cause gastrointestinal problems?

Berberine is generally safe, but it may have some side effects, mainly gastrointestinal. Common problems include:

• nausea
• Diarrhea
• constipation
• Swelling
• stomach discomfort

Pregnant or breastfeeding women should avoid berberine because it can pass through the placenta and into breast milk. It may also interact with certain medications, especially those that affect hepatic metabolism.

Which is better for weight loss, berberine or metformin?

Berberine is often compared to metformin, a medication for the management of type 2 diabetes. Both can help with weight loss, but they work in different ways. “Metformin primarily reduces hepatic glucose production and increases insulin sensitivity. In contrast, the benefits of berberine come from its natural properties, including the ability to activate AMPK,” the expert says. Metformin has a long history of use and may result in slightly greater weight loss than berberine.

(Note to readers: This article is for informational purposes only and is not a substitute for professional medical advice. Always seek the advice of your doctor with any questions you have about any medical condition.)