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Scientists found that H5N1 avian avian influenza does not work well against the frequently used flu antiviral cows.
Existing antivirals may be less effective against this H5N1 bird flu stream, and prevention measures, such as avoiding raw milk consumption and reducing risk in dairy workers, perhaps the most effective way to protect from virus.
The outbreak of H5N1 avian influenza continues in the United States, scientists working to better understand the risk of virus for human health.
The virus has been found in dairy cows’ milk and infected infected farm workers, inspiring scientists at St. Jude Children’s Research Hospital to study potential treatment.
The results showed that in a pre-pricly model, two FDA-unknown flu antivirals usually did not successfully treat severe H5N1 infections. Additionally, researchers found that the path of infection, whether through the eye, nose or mouth, significantly affects the effectiveness of treatment.
The conclusions were published in Nature Microbiology today.
“Our evidence suggests that it is difficult to treat seriously infected people with this bovine H5N1 bird flu strain,” said a similar author Richard Webbi, PhD, St. Jude Department of Host-Microbo interaction.
“Instead, reducing the risk of infection by not drinking raw milk and reducing dairy farm workers exposure, for example, the most effective intervention can occur.”
Although H5N1 infections in people are rare, there are over 60 people who have become infected with dairy exposure in the current outbreak.
Some contaminated raw cows were infected through contact with milk, such as dairy workers who were infected through splash or aerosolized particles, reaching their nose or eyes.
Given the risks to human health, scientists used a mouse model to test how each antiviral drug worked against the virus when it was obtained through three separate exposure routes.
“In general, Baloxvir [Xofluza] Causes a higher decrease in viral levels than oseltamivir [Tamiflu]But neither was it always effective, “The first writer Jeremy Jones, PhD, St. Jude Department of Host-Microbo interaction said.
Researchers studied the exposure routes that included the eye, mouth and nose, which are the most common methods of getting infected with the virus. The oral passage, which mimics raw -infected cow’s milk, produces the worst infection that was the most difficult for treatment.
Conversely, the findings showed that Baloxvir well controlled infections through the eye. These results are particularly relevant because the Ocler route appears to be a common transition path for those who work directly with dairy cows.
Also read: Bird Flu in North America: What do you know about outbreak
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